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doi: 10.1016/j.phrs.2021.105960 59 MuresanXMSlabkovEProchzkovJDrpelaSFedrRPckovMet al

doi: 10.1093/clinchem/34.2.401 97 DahelKAAl-SaffarNMFlayehKA

These patients sometimes have liver cirrhosis but frequently have a milder clinical picture [89]

However, current analytical methods often require tedious chemical derivatization, lack adequate retention and selectivity for highly polar analytes, or suffer from severe matrix effects when profiling the broader metabolic pathway